Pesquisa | SciELO

ABSTRACT The global reemergence of measles in 2018–2019 reinforces the relevance of high-coverage immunization to maintain the disease elimination. During an outbreak in the Sao Paulo State in 2019, several measles cases were reported in individuals who were adequately vaccinated according to the current immunization schedule recommends. This study aimed to assess measles IgG antibody seropositivity and titers in previously vaccinated adults. A cross-sectional study was conducted at CRIE-HC-FMUSP (Sao Paulo, Brazil) in 2019. It included healthy adults who had received two or more Measles-Mumps-Rubella vaccines (MMR) and excluded individuals with immunocompromising conditions. Measles IgG antibodies were measured and compared by ELISA (Euroimmun®) and chemiluminescence (LIASON®). The association of seropositivity and titers with variables of interest (age, sex, profession, previous measles, number of measles-containing vaccine doses, interval between MMR doses, and time elapsed since the last MMR dose) was analyzed. A total of 162 participants were evaluated, predominantly young (median age 30 years), women (69.8%) and healthcare professionals (61.7%). The median interval between MMR doses was 13.2 years, and the median time since the last dose was 10.4 years. The seropositivity rate was 32.7% by ELISA and 75.3% by CLIA, and a strong positive correlation was found between the tests. Multivariate analyses revealed that age and time since the last dose were independently associated with positivity. Despite being a single-center evaluation, our results suggest that measles seropositivity may be lower than expected in adequately immunized adults. Seropositivity was higher among older individuals and those with a shorter time since the last MMR vaccine dose.

https://doi.org/10.1590/s1678-9946202466004

Ribosomal, mitochondrial and bacterial (Wolbachia) reference sequences for Dipetalonema gracile obtained from a wild pied tamarin (Saguinus bicolor) host in Manaus, Brazil
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COSTA, Carlos Henrique Aguiar

; CRAINEY, James Lee

; VICENTE, Ana Carolina Paulo

; CONGA, David Fernandez

; GORDO, Marcelo

; LUZ, Sérgio Luiz Bessa

; DIAS, Cindy Alves

; SILVA, Túllio Romão Ribeiro da

; FERREIRA, Caroline Coelho

; NAVA, Alessandra Ferreira Dales

Acta Amazonica

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Jun 2023, Volume 53 Nº 2 Páginas 130 - 140

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT The primates that inhabit the rainforest surrounding the city of Manaus (Amazonas, Brazil) have long been recognised as potentially important reservoirs of emerging and re-emerging infectious diseases (ERIDs). PCR amplification of filarial sequences from wild-caught Simulium oyapockense has been used to incriminate potentially important Amazon-region ERID bridge vectors by showing they had previously fed on non-human primates. The broader use of filarial parasite sequences for the incrimination of biting insects as potentially important zoonotic disease vectors is limited by a paucity of primate-derived filarial parasite reference sequences which can be matched to the PCR amplified sequences obtained from insect-vector vectors. Here we have used shotgun sequencing to obtain reference data from an adult Dipetalonema gracile parasite which was found infecting a wild pied tamarin (Saguinus bicolor) in a peripheral region of Manaus. We report the parasite´s complete mitochondrial genome (which is 13,647 base pairs in length), 894,846 base pairs of its Wolbachia genome and 6,426 base pairs of its ribosomal DNA locus (spanning from the start of its 18S subunit to the end of its 28S subunit). Despite being critically endangered, S. bicolor is commonly encountered around the periphery of Manaus and in urban forest fragments. The reported sequences may be a useful reference tool for identifying ERID bridge vectors and potentially provide some insights into the amount and the nature of contact between primate pathogen reservoirs and the residents of Manaus.

RESUMO Os primatas que habitam a floresta tropical ao redor da cidade de Manaus (Amazonas, Brasil) há muito são reconhecidos como reservatórios potencialmente importantes de doenças infecciosas emergentes e reemergentes. Sequências de DNA de parasitas filariais detectadas por PCR em amostras de Simulium oyapockense foram usadas para demonstrar que eles haviam se alimentado anteriormente de primatas não humanos e, dessa maneira, incriminar vetores-ponte da região amazônica. O uso mais amplo de detecção de parasitas filariais para a incriminação de vetores-ponte é limitado por uma escassez de sequências referência de parasitas filarias obtidas de hospedeiros. Aqui nós usamos o sequenciamento tipo shotgun para obter dados de referência de um parasita adulto Dipetalonema gracile encontrado infectando um sauim-de-coleira, Saguinus bicolor no entorno de Manaus. Relatamos o genoma mitocondrial completo do parasita (que tem 13.647 pares de bases de comprimento), 894.846 pares de bases de seu genoma de Wolbachia e 6.426 pares de bases de seu locus de DNA ribossômico (desde o início de sua subunidade 18S até o final de sua subunidade 28S). Apesar de criticamente ameaçado, S. bicolor é comumente encontrado no entorno de Manaus e em fragmentos florestais urbanos. As sequências relatadas podem ser uma ferramenta de referência útil para identificar vetores ponte e potencialmente fornecer algumas informações sobre o contato entre reservatórios de patógenos de primatas e os moradores de Manaus.

https://doi.org/10.1590/1809-4392202201741

Early Six-Minute Walk Test May Predict Midterm Outcomes Following Coronary Artery Bypass Grafting
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Pauletti, Hayanne O.

; Gomes, Walter José

; Rocco, Isadora S.

; Viceconte, Marcela

; Garcia, Bruna Caroline Matos

; Marcondi, Natasha O.

; Bublitz, Caroline B.

; Costa, Ariele dos Santos

; Paiva, Thâmara Pequeno de

; Spina, Giovanna Domingues

; Begot, Isis

; Silva, Célia Camelo

; Moreira, Rita Simone L.

; Branco, João Nelson Rodrigues

; Vargas, Guilherme Flora

; Hossne Jr., Nelson A.

; Arena, Ross

; Guizilini, Solange

Brazilian Journal of Cardiovascular Surgery

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2023, Volume 38 Nº 4 elocation e20220459

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: This study aims to investigate the ability of the six-minute walk distance (6MWD) as a prognostic marker for midterm clinical outcomes three months after coronary artery bypass grafting (CABG), to identify possible predictors of fall in 6MWD in the early postoperative period, and to establish the percentage fall in early postoperative 6MWD, considering the preoperative baseline as 100%. Methods: A prospective cohort of patients undergoing elective CABG were included. The percentage fall in 6MWD was assessed by the difference between preoperative and postoperative day (POD) five. Clinical outcomes were evaluated three months after hospital discharge. Results: There was a significant decrease in 6MWD on POD5 compared with preoperative baseline values (percentage fall of 32.5±16.5%, P<0.0001). Linear regression analysis showed an independent association of the percentage fall of 6MWD with cardiopulmonary bypass (CPB) and preoperative inspiratory muscle strength. Receiver operating characteristic curve analysis revealed that the best cutoff value of percentage fall in 6MWD to predict poorer clinical outcomes at three months was 34.6% (area under the curve = 0.82, sensitivity = 78.95%, specificity = 76.19%, P=0.0001). Conclusion: This study indicates that a cutoff value of 34.6% in percentage fall of 6MWD on POD5 was able to predict poorer clinical outcomes at three months of follow-up after CABG. Use of CPB and preoperative inspiratory muscle strength were independent predictors of percentage fall of 6MWD in the postoperative period. These findings further support the clinical application of 6MWD and propose an inpatient preventive strategy to guide clinical management over time.

https://doi.org/10.21470/1678-9741-2022-0459

Early Six-Minute Walk Test May Predict Midterm Outcomes Following Coronary Artery Bypass Grafting
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Pauletti, Hayanne O.

; Gomes, Walter José

; Rocco, Isadora S.

; Viceconte, Marcela

; Garcia, Bruna Caroline Matos

; Marcondi, Natasha O.

; Bublitz, Caroline B.

; Costa, Ariele dos Santos

; Paiva, Thâmara Pequeno de

; Spina, Giovanna Domingues

; Begot, Isis

; Silva, Célia Camelo

; Moreira, Rita Simone L.

; Branco, João Nelson Rodrigues

; Vargas, Guilherme Flora

; Hossne Jr., Nelson A.

; Arena, Ross

; Guizilini, Solange

Brazilian Journal of Cardiovascular Surgery

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2023, Volume 38 Nº 4 elocation e20220459

Resumo: En | Texto: En | PDF: En

https://doi.org/10.21470/1678-9741-2022-0459

COVID-19 in the Perioperative Period of Cardiovascular Surgery: the Brazilian Experience
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Gomes, Walter J.

; Rocco, Isadora

; Pimentel, Wallace S.

; Pinheiro, Aislan H. B.

; Souza, Paulo M. S.

; Costa, Luiz A. A.

; Teixeira, Marjory M. P.

; Ohashi, Leonardo P.

; Bublitz, Caroline

; Begot, Isis

; Moreira, Rita Simone L

; Hossne Jr, Nelson A.

; Vargas, Guilherme F.

; Branco, João Nelson R.

; Teles, Carlos A.

; Medeiros, Eduardo A. S.

; Sáfadi, Camila

; Rampinelli, Amândio

; Moratelli Neto, Leopoldo

; Rosado, Anderson Rosa

; Mesacasa, Franciele Kuhn

; Capriata, Ismael Escobar

; Segalote, Rodrigo Coelho

; Palmieri, Deborah Louize da Rocha Vianna

; Jardim, Amanda Cristina Mendes

; Vianna, Diego Sarty

; Coutinho, Joaquim Henrique de Souza Aguiar

; Jazbik, João Carlos

; Coutinho, Henrique Madureira da Rocha

; Kikuta, Gustavo

; Almeida, Zely Sant'Anna Marotti de

; Feguri, Gibran Roder

; Lima, Paulo Ruiz Lucio de

; Franco, Anna Carolina

; Borges, Danilo de Cerqueira

; Cruz, Felipe Ramos Honorato De La

; Croti, Ulisses Alexandre

; Borim, Bruna Cury

; Marchi, Carlos Henrique De

; Goraieb, Lilian

; Postigo, Karolyne Barroca Sanches

; Jucá, Fabiano Gonçalves

; Oliveira, Fátima Rosane de Almeida

; Souza, Rafael Bezerra de

; Zilli, Alexandre Cabral

; Mas, Raul Gaston Sanchez

; Bettiati Junior, Luiz Carlos

; Tranchesi, Ricardo

; Bertini Jr, Ayrton

; Franco, Leandro Vieira

; Fernandes, Priscila

; Oliveira, Fabiana

; Moraes Jr, Roberto

; Araújo, Thiago Cavalcanti Vila Nova de

; Braga, Otávio Penna

; Pedrosa Sobrinho, Antônio Cavalcanti

; Teixeira, Roberta Tavares Barreto

; Camboim, Irla Lavor Lucena

; Gomes, Eduardo Nascimento

; Reis, Pedro Horigushi

; Garcia, Luara Piovan

; Scorsioni, Nelson Henrique Goes

; Lago, Roberto

; Guizilini, Solange

Brazilian Journal of Cardiovascular Surgery

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Dez 2021, Volume 36 Nº 6 Páginas 725 - 735

Resumo: En | Texto: En | PDF: En

Abstract Introduction: We investigated the clinical course and outcomes of patients submitted to cardiovascular surgery in Brazil and who had developed symptoms/signs of coronavirus disease 2019 (COVID-19) in the perioperative period. Methods: A retrospective multicenter study including 104 patients who were allocated in three groups according to time of positive real time reverse transcriptase-polymerase chain reaction (RT-PCR) for the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2): group 1, patients who underwent cardiac surgery > 10 days after positive RT-PCR; group 2, patients with a positive RT-PCR within 10 days before or after surgery; group 3, patients who presented positive RT-PCR > 10 days after surgery. The primary outcome was mortality and secondary outcomes were postoperative complications, intensive care unit (ICU) length of stay, and postoperative days of hospitalization. Results: The three groups were similar with respect to age, the European System of Cardiac Operative Risk Evaluation score, and comorbidities, except hypertension. Postoperative complications and death were significantly higher in groups 2 and 3 than in group 1, and no significant difference between groups 2 and 3 was seen. Group 2 showed a high prevalence of surgery performed as an urgent procedure. Although no significant differences were observed in ICU length of stay, total postoperative hospitalization time was significantly higher in group 3 than in groups 1 and 2. Conclusion: COVID-19 affecting the postoperative period of patients who underwent cardiovascular surgery is associated with a higher rate of morbidity and mortality. Delaying procedures in RT-PCR-positive patients may help reduce risks of perioperative complications and death.

https://doi.org/10.21470/1678-9741-2021-0960

Blue Glow Sticks: Cinnamic Acids and Arylacrylonitriles with Liquid-Crystalline Properties and Highly Fluorescent
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Tavares, Aline

; Costa, Rebeca O.

; Weber, Caroline S. B.

; Cazati, Thiago

; Ceschi, Marco A.

; Vieira, André A.

; Merlo, Aloir A.

Journal of the Brazilian Chemical Society

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Jan 2021, Volume 32 Nº 1 Páginas 98 - 109

Resumo: En | Texto: En | PDF: En

Five new π-conjugated chromophores derived from acrylic acid and acrylonitrile were synthesized and their thermal and photophysical behaviors were analyzed. They were designed and synthesized through Knoevenagel condensations between arylacetylenebenzaldehydes and a methylene group activated from cyanoacetic and malonic acids. The characterization of the target compounds was performed by Fourier transform infrared spectroscopy (FTIR), 1H nuclear magnetic resonance (NMR), 13C NMR, thermogravimetric analysis (TGA), absorption and emission spectroscopy techniques. Arylcinnamic acids were obtained as pure E-isomers. On the other hand, arylacrylonitrile was obtained as a mixture of E/Z-isomers and the pure E-isomer was isolated in chromatographic columns. The liquid crystal properties were investigated through differential scanning calorimetry and polarized optical microscopy. All chromophores displayed smectic and nematic mesophases. These materials displayed intense fluorescence under UV-Vis light excitation. The maximum absorption peaks were observed between 342-356 nm while emission varied from 428 to 460 nm in chloroform solution. Higher values for the quantum fluorescence yield were associated with acrylic acids compared to arylacrylonitriles. The solvatochromism studies of the materials showed a significant increase in the red-shift of the fluorescence spectra as the polarity of the solvent increased. In some cases, a variation in the emission wavelength from the blue to the green region of the spectrum was observed.

https://doi.org/10.21577/0103-5053.20200159 292 downloads

Análise temporal da desigualdade em escolaridade no tabagismo e consumo abusivo de álcool nas capitais brasileiras
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Wendt, Andrea

; Costa, Caroline S.

; Costa, Francine S.

; Malta, Deborah Carvalho

; Crochemore-Silva, Inácio

Cadernos de Saúde Pública

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2021, Volume 37 Nº 4 elocation e00050120

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Estudo de tendência temporal com o objetivo de avaliar as desigualdades no tabagismo e no consumo abusivo de álcool, considerando a escolaridade como proxy de nível socioeconômico, de acordo com sexo e regiões brasileiras. Foram utilizados dados do Vigilância de Fatores de Risco e Proteção para Doenças Crônicas por Inquérito Telefônico (Vigitel) coletados entre 2006 e 2017. Os desfechos foram o consumo abusivo de bebidas alcoólicas e o fumo. As desigualdades foram avaliadas com base na escolaridade, com dupla estratificação por sexo e regiões brasileiras. Para avaliar a tendência das prevalências dos desfechos e suas desigualdades foi usada a regressão linear ponderada pelos quadrados mínimos da variância. A prevalência de consumo abusivo de álcool aumentou em mulheres, de 7,8% (2006) para 12,2% (2017), e foi maior sempre entre os mais escolarizados. A prevalência de tabagismo diminuiu para homens e mulheres e foi maior sempre entre os menos escolarizados. A desigualdade no consumo de álcool entre os grupos de escolaridade parece ter aumentado ao longo do tempo, com maior magnitude entre as mulheres, mas a desigualdade no tabagismo parece estar diminuindo. Em algumas regiões do país, as medidas de desigualdade sugerem estabilidade e em outras um aumento da desigualdade para o consumo de álcool (Sudeste, Sul e Centro-oeste, entre as mulheres) e diminuição para o tabagismo (todas as regiões, exceto Sudeste, entre os homens; Nordeste e Centro-oeste, entre as mulheres). Apesar dos avanços na redução do tabagismo, as desigualdades na escolaridade persistem e estão presentes também em relação ao álcool. Os desfechos têm comportamentos opostos, portanto, estratégias devem ser focadas em cada um dos problemas, a fim de reduzir as desigualdades existentes.

Abstract: This was a time trend study aimed at assessing inequalities in smoking and abusive alcohol consumption, considering schooling as a proxy for socioeconomic status, according to sex and region of Brazil. The study used data from the Risk and Protective Factors Surveillance System for Chronic Non-Comunicable Diseases Through Telephone Interview (Vigitel) survey collected from 2006 to 2017. The outcomes were abusive alcohol consumption and smoking. The inequalities were assessed based on schooling, with double stratification by sex and major geographic region. Weighted linear least squares regression was used to assess the trend in prevalence of outcomes and their inequalities. Prevalence of abusive alcohol consumption increased in women, from 7.8% in 2006 to 12.2% in 2017 and was consistently higher among individuals with more schooling. Prevalence of smoking decreased in both men and women and was consistently higher among those with less schooling. Inequality in alcohol consumption between schooling groups appears to have increased over time, higher in women, but inequality in smoking appears to have decreased. In some regions of Brazil, the measures of inequality suggest stability and in others an increase in inequality in alcohol consumption (Southeast, South, and Central regions in women) and a decrease in smoking (all regions except the Southeast in men; Northeast and Central in women). Despite the strides in smoking reduction, inequalities persist in schooling and are also present in alcohol consumption. The outcomes show opposite trends, so strategies should focus on each of the problems in order to reduce existing inequalities.

Resumen: Estudio de tendencia temporal, con el objetivo de evaluar las desigualdades en el tabaquismo y consumo abusivo de alcohol, considerando la escolaridad como proxy de nivel socioeconómico, de acuerdo con el sexo y regiones brasileñas. Se utilizaron datos de Vigilancia de Factores de Riesgo y Protección para Enfermedades Crónicas No Transmisibles por Entrevista Telefónica (Vigitel), recogidos entre 2006 y 2017. Los resultados fueron el consumo abusivo de bebidas alcohólicas y tabaco. Las desigualdades se evaluaron a partir de la escolaridad, con doble estratificación por sexo y regiones brasileñas. Para evaluar la tendencia de las prevalencias de los resultados y sus desigualdades se utilizó la regresión lineal por mínimos cuadrados ponderados de la variancia. La prevalencia de consumo abusivo de alcohol aumentó en mujeres de 7,8% (2006) a 12,2% (2017) y fue siempre mayor entre los más escolarizados. La prevalencia de tabaquismo disminuyó en hombres y mujeres, y siempre fue mayor entre los menos escolarizados. La desigualdad en el consumo de alcohol entre los grupos de escolaridad parece que ha aumentado a lo largo del tiempo, con mayor magnitud entre las mujeres, pero la desigualdad en el tabaquismo parece estar disminuyendo. En algunas regiones del país, las medidas de desigualdad sugieren estabilidad y en otras un aumento de la desigualdad en el consumo de alcohol (Sudeste, Sur y Centro-oeste, entre las mujeres) y disminución en el tabaquismo (todas las regiones, excepto la Sudeste, entre los hombres; Nordeste y Centro-oeste, entre las mujeres). A pesar de los avances en la reducción del tabaquismo, las desigualdades en la escolaridad persisten y están presentes también en relación con el alcohol. Los resultados tienen comportamientos opuestos, por lo tanto, las estrategias deben centrarse en cada uno de los problemas, a fin de reducir las desigualdades existentes.

https://doi.org/10.1590/0102-311x00050120 710 downloads

Análise temporal da desigualdade em escolaridade no tabagismo e consumo abusivo de álcool nas capitais brasileiras
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Wendt, Andrea

; Costa, Caroline S.

; Costa, Francine S.

; Malta, Deborah Carvalho

; Crochemore-Silva, Inácio

Cadernos de Saúde Pública

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2021, Volume 37 Nº 4 elocation e00050120

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/0102-311x00050120

Gender-related differences in the modulation of anthropometric, biochemical, and immune markers by physical activity in hypertensive and diabetic individuals
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SANTOS, DÉBORAH C. DOS

; RIBEIRO, ISRAEL S.

; LOPES, DIEGO PATRICK S.

; PEREIRA, ÍTALO S.

; SANTOS, DENISAR P.

; MUNIZ, IGOR P.R.

; LIMA, FERNANDA M. DA SILVA

; COSTA, ANDRESSA ANTÔNIA S.

; SOUZA, DANIELA DA SILVA P.

; CALADO, STÉFANO PEDRO DE MELO

; GONÇALVES, CAROLINE V.

; GALANTINI, MARIA POLIANA L.

; LOPES, DANILO N.

; SILVA, ROBSON A.A. DA

; SANTOS, GILVANÉIA S.

Anais da Academia Brasileira de Ciências

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2021, Volume 93 elocation e20201905

Resumo: En | Texto: En | PDF: En

Abstract Systemic arterial hypertension (SAH) and type 2 diabetes mellitus (T2DM) compose the two major noncommunicable chronic inflammatory diseases. Physical activity has been shown as a promising complementary approach to control the systemic inflammation. However, it is still unclear whether this modulation is gender-dependent. The objective of this study was evaluate the gender-related influence of physical activity on the inflammatory response and biochemical profile of individuals with SAH and T2DM. An international physical activity questionnaire was applied to 376 individuals diagnosed with SAH and T2DM in order to access their exercises routine and was evaluated the influence of physical activity in biochemical, anthropometrical, and immunological markers involved in these disorders in men and women. Even though active individuals have exhibited lower serum levels of IL-1β, IFN-γ, TNF-α, and IL-17A, the ratios between IL-10 and all inflammatory cytokines were higher in men than in women. Physically active individuals also demonstrated increased HDL/LDL and HDL/VLDL ratios. Moreover, multiple correlations revealed that in active women both IL-10 and TNF-α serum levels positively correlate with fasting glucose levels, and were negatively associated with HDL levels. Our findings suggest that gender-related differences dictate a distinct crosstalk between inflammatory and biochemical markers in physically active individuals.

https://doi.org/10.1590/0001-3765202120201905 1 downloads

10.

PERSONAL VALUES AND INTRAGROUP RELATIONSHIP: THE CASE OF THE POLICE TACTICAL GROUPS IN BRASÍLIA
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DIAS, FAGNER O.

; REYES JUNIOR, EDGAR

; COSTA, CAROLINE C. B.

; BARROS, ANDRÉIA E. S.

RAM. Revista de Administração Mackenzie

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2021, Volume 22 Nº 5 elocation eRAMG210010

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Este estudo tem como objetivo descrever como os valores pessoais dos membros de grupos de trabalho especializado impactam seus relacionamentos intragrupo baseados na confiança profissional e pessoal. Originalidade/valor: Três pontos norteiam as contribuições do presente estudo: 1. a consolidação de que a análise da confiança em grupos de trabalho tem resultados distintos nas relações instrumental (confiança profissional ou de reputação) e experimental (confiança pessoal ou de amizade) quando se verifica a diferença na predominância de valores pessoais para cada tipo de relacionamento; 2. a utilização da teoria funcionalista dos valores humanos e de técnicas da análise de redes sociais (ARS) em conjunto com técnicas clássicas quantitativas, como a ANOVA e a regressão múltipla; 3. em termos gerenciais, a verificação dos valores pessoais que favorecem a organização e o modo como se estruturam as relações de confiança no grupo. Design/metodologia/abordagem: O presente estudo caracteriza-se como uma pesquisa de campo descritiva com abordagem quantitativa. Foi aplicada uma survey com 171 participantes de dois grupos táticos da polícia de Brasília, utilizando o questionário QVB de valores funcionalistas e um questionário com oito perguntas sobre os relacionamentos instrumental e expressivo. Utilizaram-se a análise fatorial confirmatória para evidenciar a validade do instrumento e a ARS para os relacionamentos de confiança. No caso das relações entre valores e relacionamentos, adotaram-se a ANOVA e a regressão múltipla. Resultados: Os grupos táticos apresentaram características de valores pessoais mais pragmáticos e com menos valorização de individualismo, denotando características de valorização da execução e do coletivismo intragrupo. Os valores normativo e suprapessoal foram negativamente relacionados, respectivamente, às relações de amizade e profissionais, enquanto o valor realização foi positivamente relacionado às duas relações de confiança.

ABSTRACT Objectives: This article aims to describe how the personal values of members of specialized workgroups impact their intra-group relationships based on professional and personal trust. Originality/value: The contributions of this study are threefold: 1. the consolidation that the analysis of trust in work groups has different results in the instrumental (professional or reputation trust) and the experimental (personal or friendship trust) relationship when verifying difference in the predominance of personal values for each type relationship; 2. the use of the functionalist theory of human values and to the use of social network analysis techniques and in conjunction with classical quantitative techniques such as ANOVA and multiple regression; 3. the verification of personal values that contributes to the organization and how trust relationships are structured in the group. Design/methodology/approach: The present study is characterized as descriptive field research with a quantitative approach. A survey was conducted with 171 participants from the two tactical groups of the Brasília police, using the Basic Values Questionnaire (BVQ) questionnaire of functionalist values and a questionnaire with eight questions about the instrumental and expressive relationship. Confirmatory factor analysis was used to evidence the validity of the instrument, analysis of social networks (ASN) for trust relationships and ANOVA, and multiple regression for relationships between values and relationships. Findings: The tactical groups presented characteristics of more pragmatic personal values and with less appreciation of individualism, denoting characteristics of appreciation of execution and intragroup collectivism. The normative and supra-personal values were negatively related, respectively, to friendship and professional relationships, while the achievement value was positively related to both trust relationships.

https://doi.org/10.1590/1678-6971/eramg210010 145 downloads

11.

Chemical Prospection of Qualea grandiflora Mart. Fruit and Stem Extracts and Their in vitro and in vivo Antiplasmodial Activity
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Gonçalves Neto, Geraldo S.

; Costa, Romário P. da

; Zanini, Camila L.

; Aguiar, Anna Caroline C.

; Souza, Juliana O. de

; Souza, Guilherme E. de

; Severino, Richele P.

; Cass, Quezia B.

; Cruz, Fábio C.

; Oliva, Glaucius

; Guido, Rafael V. C.

; Sousa, Lorena R. F. de

Journal of the Brazilian Chemical Society

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Jul 2020, Volume 31 Nº 7 Páginas 1475 - 1484

Resumo: En | Texto: En | PDF: En

Qualea grandiflora Mart. (“pau-terra”) is a medicinal plant symbolic from Cerrado biome. Qualea species reportedly have antiparasitic properties, but their active compounds have yet to be identified. In this study, we investigated the antiplasmodial activity of Q. grandiflora fruit and stem extracts against Plasmodium falciparum. The polar extracts of both fruits and stems showed promising in vitro antiplasmodial activity against sensitive and resistant P. falciparum strains (half-maximal inhibitory concentration (IC50) = 1.2 and 4.2 ng mL-1, respectively), low cytotoxicity against human hepatic cells (IC50HepG2 ≥ 400 ng mL-1), and a noteworthy selectivity index (SI ≥ 322 and ≥ 96, respectively). The fruit ethanolic extract revealed significant oral efficacy at 100 mg kg-1 in a mouse model of P. berghei malaria (100% reduction in parasitemia on day 5 post-infection). To investigate the chemical composition of the extracts, we developed a method involving liquid chromatography-high resolution quadrupole-time of flight mass spectrometer. The chemical profiling of active extracts indicated 32 compounds, including gallotannins, ellagic acid derivatives and flavonoids. The common component in the active polar extracts was found to be ellagic acid (EA), which may contribute favorably to the in vitro and in vivo inhibitory activity observed in this study.

https://doi.org/10.21577/0103-5053.20200034 253 downloads

12.

Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Palythoa caribaeorum
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Pinto, Francisco C. L.

; Silveira, Edilberto R.

; Vasconcelos, Ana Caroline L.

; Florêncio, Katharine G. D.

; Oliveira, Francisca A. S.

; Sahm, Bianca B.

; Costa-Lotufo, Letícia V.

; Bauermeister, Anelize

; Lopes, Norberto P.

; Wilke, Diego V.

; Pessoa, Otília D. L.

Journal of the Brazilian Chemical Society

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Jan 2020, Volume 31 Nº 1 Páginas 143 - 152

Resumo: En | Texto: En | PDF: En

A Streptomyces sp. (BRA-384) was selected among nine strains of bacteria isolated from the zoanthids Palythoa caribaeorum due to the high cytotoxic activity presented by its EtOAc extract (inhibitory concentration mean (IC50) of 2 ng mL-1) against colon cancer cell line. From the EtOAc extract of BRA-384 three new chemical entities (A6, A7 and A8) and one dextrorotatory chromomycin (A5), a promising class of anticancer compounds, were identified. The cytotoxicity of chromomycins A5 to A8 was tested against five tumor cell lines (HCT 116 (human colon adenocarcinoma), MCF-7 (human breast carcinoma), PC-3M (human metastatic prostate cancer), 501-mel (human metastatic melanoma) and MM200 (metastatic melanoma)). All chromomycins were highly potent showing IC50 values from 0.2 to 133 nM. Chromomycin A5 was consistently the most potent over all tested cells (IC50 values from 0.2 in MM200 to 7.9 nM in PC-3M), inclusive when compared to the standard chemotherapeutic agent doxorubicin, that presented IC50 values ranging from 147 to 568 nM against MM200 and MCF-7, respectively.

https://doi.org/10.21577/0103-5053.20190144 391 downloads

13.

Intenção de amamentar, duração do aleitamento materno e motivos para o desmame: um estudo de coorte, Pelotas, RS, 2014
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Amaral, Sheila Afonso do

; Bielemann, Renata Moraes

; Del-Ponte, Bianca

; Valle, Neiva Cristina Jorge

; Costa, Caroline dos Santos

; Oliveira, Martiele da Silva

; Santos, Iná S.

Epidemiologia e Serviços de Saúde

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2020, Volume 29 Nº 1 elocation e2019219

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Objetivo: avaliar a intenção materna de amamentar, duração do aleitamento materno até os 24 meses e os motivos para o desmame no primeiro ano de vida. Métodos: trata-se de estudo de coorte realizado em Pelotas, RS, Brasil, com participantes do Multi-Centre Body Composition Study; para a análise da duração da amamentação, utilizou-se tábua de vida. Resultados: das 1.377 mães rastreadas, 74,3% relataram intenção de amamentar exclusivamente até os 6 meses, enquanto 91,1% pretendiam prolongar o aleitamento materno até pelo menos os 12 meses; até pelo menos 6 meses, 58,0% das crianças foram amamentadas; a mediana da amamentação foi de 10,8 meses (IIQ: 5,8 a 23,0); os principais motivos relatados para desmame foram leite insuficiente (57,3%), retorno ao trabalho/escola (45,5%) e recusa inexplicável do bebê (40,1%). Conclusão: apesar da intenção de amamentar, persistem barreiras estruturais e sociais que interferem no sucesso da amamentação, especialmente as relacionadas ao trabalho materno.

Abstract Objective: to evaluate maternal intention to breastfeed, duration of breastfeeding up to 24 months-of-age and reasons for weaning in the first year of life. Methods: this was a cohort study conducted in Pelotas, RS, Brazil, with participants from the Multi-Center Body Composition Study; a life table was used to analyze duration of breastfeeding. Results: of the 1377 mothers screened, 74.3% reported intending to exclusively breastfeed up until 6 months, while 91.1% intended to prolong breastfeeding until at least 12 months; 58.0% of children were breastfed up to at least 6 months; median breastfeeding duration was 10.8 months (IQR: 5.8 - 23.0); the main reasons reported for weaning were insufficient breast milk (57.3%), return to work/school (45.5%), and unexplained refusal by the baby (40.1%). Conclusion: the results show that despite the intention to breastfeed, there are still structural and social barriers that interfere with successful breastfeeding, especially those related to working mothers.

Resumen Objetivo: evaluar la intención materna de amamantar, la duración de la lactancia materna hasta los 24 meses de edad y los motivos para la ablactación en el primer año de vida. Métodos: se trata de un estudio de cohorte realizado en Pelotas, RS, Brasil, con participantes del Multi-Centre Body Composition Study; para el análisis de la duración de la lactancia, se utilizó la tabla de vida. Resultados: de las 1.377 madres rastreadas, el 74,3% tenía intención de amamantar exclusivamente hasta los 6 meses, mientras que el 91,1% pretendía prolongarla hasta por lo menos los 12 meses; el 58,0% de los niños fueron amamantados hasta, al menos, los 6 meses; la mediana de la lactancia fue de 10,8 meses (IIQ: 5,8 a 23,0); los principales motivos para el destete fueron: leche insuficiente (57,3%), retorno al trabajo/escuela (45,5%) y la negativa inexplicable del bebé (40,1%). Conclusión: los resultados muestran que, a pesar de la intención de amamantar, todavía hay barreras estructurales y sociales que interfieren en el éxito de la lactancia, especialmente los relacionados con el trabajo materno.

https://doi.org/10.5123/s1679-49742020000100024

14.

Intenção de amamentar, duração do aleitamento materno e motivos para o desmame: um estudo de coorte, Pelotas, RS, 2014
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Amaral, Sheila Afonso do

; Bielemann, Renata Moraes

; Del-Ponte, Bianca

; Valle, Neiva Cristina Jorge

; Costa, Caroline dos Santos

; Oliveira, Martiele da Silva

; Santos, Iná S.

Epidemiologia e Serviços de Saúde

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2020, Volume 29 Nº 1 elocation e2019219

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.5123/s1679-49742020000100024 2816 downloads

15.

Nutritional intervention may improve migraine severity: a pilot study
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COSTA, Aline Bárbara Pereira

; RODRIGUES, Ana Maria dos Santos

; MARTINS, Laís Bhering

; SANTOS, Luana Caroline dos

; GOMEZ, Rodrigo S.

; TEIXEIRA, Antonio Lucio

; FERREIRA, Adaliene Versiani Matos

Arquivos de Neuro-Psiquiatria

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Out 2019, Volume 77 Nº 10 Páginas 723 - 730

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RESUMO Estudos investigaram o papel da intervenção nutricional, focada no consumo de alimentos “gatilhos” ou na alteração de peso, na melhora da migrânea. Porém, mudanças na qualidade da dieta ainda não foram abordadas. Objetivo Investigar se intervenção nutricional focada na qualidade da dieta e peso saudável pode melhorar parâmetros clínicos em mulheres com migrânea. Métodos Estudo de intervenção, não controlado e não randomizado. As mulheres receberam plano alimentar individualizado e orientações nutricionais, conforme o diagnóstico nutricional. Dados antropométricos, clínicos e alimentares foram medidos uma vez por mês durante três meses. Recordatório alimentar de 24 horas forneceu informações sobre o consumo alimentar. Qualidade da dieta foi avaliada pelo Índice Brasileiro de Alimentação Saudável (IQD-R). Os questionários Migraine Disability Test (MIDAS) e Headache Impact Test, versão 6 (HIT-6) avaliaram a incapacidade gerada pela enxaqueca e o Inventário de Depressão de Beck (BDI) investigou sintomas depressivos. Resultados Cinquenta e duas mulheres com 44,0 ± 13,0 anos participaram da amostra. Características antropométricas e consumo de energia, macronutrientes e fibras não se alteraram depois da intervenção. No entanto, os escores do IQD-R melhoraram após 60 e 90 dias de intervenção. Os escores do BDI e do HIT-6 diminuíram após 60 e 90 dias, respectivamente. A mudança no escore do IQD-R correlacionou de maneira negativa com a gravidade da enxaqueca avaliada pelo HIT-6 ao final da intervenção. Conclusões O manejo da qualidade da dieta pode ser estratégia para melhorar a gravidade da migrânea, independente do estado nutricional e da mudança de peso dos pacientes.

ABSTRACT Although some studies have investigated the role of nutritional intervention on migraine, they had focused on triggers or on weight change and, to the best of our knowledge, none studied diet quality. Objective To investigate whether nutritional intervention focused on improving diet quality and healthy weight can promote improvement in clinical parameters of women with migraine. Methods Non-controlled and non-randomized intervention study conducted for 90 days. Women received an individualized diet meal plan and nutritional orientation according to their nutritional diagnosis. Anthropometric, clinical and nutritional data were measured once a month. Diet energy content and macronutrients were evaluated using 24-hour dietary recall. Diet quality was assessed through the Brazilian Healthy Eating Index–Revised (BHEI-R). The Migraine Disability Assessment and Headache Impact Test version 6 were used to assess the severity of migraine, and the Beck Depression Inventory evaluated depressive symptoms. Results Fifty-two women aged 44.0 ± 13.0 years were enrolled. Anthropometric characteristics, energy, macronutrients and fiber intake did not change after intervention. However, the BHEI-R scores improved after 60 and 90 days of intervention. Concurrent to this, the Beck Depression Inventory scores and Headache Impact Test scores decreased after 60 and 90 days, respectively. The change in the BHEI-R score was negatively correlated with the migraine severity as assessed by the Headache Impact Test at the end of the intervention. Conclusions We concluded that the management of diet quality may be a good strategy for improving migraine severity, regardless of the nutritional status and weight change.

https://doi.org/10.1590/0004-282x20190121 2265 downloads

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